Modeling of an initial stage of bone fracture healing

Bone fracture healing pdf

Does the cellular composition of the initial fracture hematoma account for scarless bone healing ?

Introduction: Bone healing involves a cascade of events that is initiated by the formation of a hematoma and an inflammatory response. During this initial phase, immune cells at the fracture site release cytokines leading to the recruitment of effector cells. It was shown that the fracture hematoma (FH) is essential for the initiation of the healing cascade [1], but the cellular composition of ...

An improved murine femur fracture device for bone healing studies.

Murine models are commonly used to investigate bone healing and test new treatments before human trials. Our objective was to design an improved murine femur fracture device and determine optimal mass and velocity settings for maximal likelihood of transverse fracture. Fracture reproducibility was maximized using an adjustable kinetic energy level, a novel mouse positioning system and an electr...

The effects of flexible fixation on early stage bone fracture healing

The mechanical microenvironment at a fracture site could potentially influence the outcomes of bone fracture healing. It is known that, should the fixation construct be too stiff, or the gap between the fracture ends be too large, bones are less likely to heal. Flexible fixation or so-called “biological fixation” has been shown to encourage the formation of fracture callus, and therefore result...

Bone injury and fracture healing biology.

OBJECTIVE To better comprehend the molecular structure and physiological function of the housefly larval peritrophic matrix (PM), a mass spectrometry approach was used to investigate the PM protein composition. METHODS The PM was dissected from the midgut of the third instar larvae, and protein extracted from the PM was evaluated using SDS-PAGE. A 1D-PAGE lane containing all protein bands was...